[UK Biobank Resource & Mayo Clinic]
“»ç°ú(Apple)" üÇü- ´ëÀå¾Ï ¹ß»ý, ´ë»çÁõÈıº À§Çè ³ô´Ù
½Åü üÇü(Associations of body shape index, ABSI)°ú ´ëÀå¾Ï ¹ß»ý À§Çè »çÀÌÀÇ ¿¬°ü¼º¿¡ ´ëÇÑ ¿¬±¸°¡ ¹ßÇ¥µÇ¾î ÁÖ¸ñÀ» ¹Þ°í ÀÖ´Ù. ¿¬±¸ÀÚ·á´Â ¿µ±¹ ¹ÙÀÌ¿À¹ðÅ©(UK Biobank)¿¡ µî·ÏµÈ ³²¼º 15,520¸í, ¿©¼º 16,548¸íÀ» ´ë»óÀ¸·Î 32¸¸¸í ÀÌ»óÀÇ µ¥ÀÌÅ͸¦ ±â¹ÝÀ¸·Î ºÐ¼® ¹ßÇ¥ÇÏ¿´´Ù. ÀÌÁ¦±îÁö ¼öÇàµÈ ´ëÀå¾Ï°ú °ü·ÃµÈ ¼±Çà ¿¬±¸¿¡¼´Â ÁÖ·Î À°·ù ¼·Ãë, °úÀ½, Èí¿¬, °¡°øÀ° µîÀÇ ¼·Ãë¿Í °ü·ÃµÈ ½Ä½À°ü°ú »ýÈ°¾ç½Ä¿¡ °ü·ÃµÈ ¿¬±¸°¡ ÁÖ·ù¸¦ ÀÌ·ç¾ú´Ù. ÇÏÁö¸¸ À̹ø ¿¬±¸¿¡¼´Â ´ëÀå¾Ï ¹ßº´ À§Çè°ú ½ÅüÀ¯Çü »çÀÌÀÇ ¿¬°ü¼ºÀ» »ìÆ캸¾Ò´Ù. ±×¸®°í ÀÚ±â°ø¸í¿µ»ó(MRI) ÃøÁ¤À» ÅëÇØ ³²¼º 3,997¸í, ¿©¼º 4,402¸í¿¡ ´ëÇØ ´ëÀå¾Ï ¹ßº´°ú À§Çè¿äÀο¡ ´ëÇÑ ÃßÀû °üÂûÀ» ÇÔ²² ½Ç½ÃÇÏ¿´´Ù.
¿¬±¸¿¡¼ ¼±Çü ¸ðµ¨À» ±â¹ÝÀ¸·Î ÇÑ ½Åü ±¸¼ºÀÇ Â÷À̸¦ Æò°¡ÇÏ°í È¥¶õ ¿äÀο¡ ´ëÇÑ Á¶Á¤µÈ Cox ºñ·Ê À§Çè ¸ðµ¨¿¡¼ ´ëÀå¾Ï À§Çè°úÀÇ ¿¬°ü¼ºÀ» Æò°¡ÇÏ°í BMI ÅëÇÑ ÀÌÁú¼ºÀ» Ž»öÇÏ¿´´Ù. ½ÅüÀÇ Ã¼Çü ºÐ·ù´Â ¾Æ·¡ 4°¡Áö·Î ºÐ·ù Á¤ÀÇÇÏ¿´°í, ABSI-by-HI üÇü Ç¥ÇöÇüÀº ü¼ººÐ¿¡ ´ëÇÑ Á¤º¸¸¦ Á¦°øÇÑ´Ù.
´ëÇü-ABSI-¼ÒÇü-HI("»ç°ú"),
¼ÒÇü-ABSI-´ëÇü-HI("¹è"),
¼ÒÇü-ABSI-¼ÒÇü-HI("½½¸²"),
´ëÇü-ABSI -large-HI("¿ÍÀ̵å")
½Åü À¯Çü¿¡ ´ëÇÑ ºÐ·ù´Â À§¿Í °°ÀÌ 4°¡Áö·Î ºÐ·ùÇÏ¿´´Ù. üÁú·®Áö¼ö, üÁß, Å°, º¹ºÎÁö¹æ·ü, Ç㸮µÑ·¹, ¾ûµ¢À̵ѷ¹ µî 6°³ ±âÁØ Áß ¸ðµÎ ³ôÀº ÀϹÝÀûÀÎ ºñ¸¸ÀÎ »ç¶÷ÀÇ Ã¼ÇüÀÌ Ã¹ ¹ø° À¯ÇüÀÌ´Ù. µÎ ¹ø° À¯ÇüÀº º¹ºÎÁö¹æ·üÀÌ ³·Àº üÇü, ¼¼ ¹ø° À¯ÇüÀº º¹ºÎÁö¹æ·üÀÌ ³ôÀº üÇü, ¸¶Áö¸· À¯ÇüÀº üÁß, üÁú·®Áö¼ö´Â ³ôÁö¸¸ Ç㸮µÑ·¹, ¾ûµ¢À̵ѷ¹°¡ ¾ãÀº üÇüÀÌ´Ù.
Fig. 1 Correlation between anthropometry and body composition. ABSI – a body shape index; ASAT – abdominal subcutaneous adipose tissue; BMI – body mass index; HC – hip circumference; HI – hip index; VAT – visceral adipose tissue; WC – waist circumference; WHI – waist-to-hip index; WHR – waist-to-hip ratio. Men – bottom-left half of each panel. Women – top-right half of each panel. Cells – show partial Pearson correlation coefficients, with adjustment for age, weight change during the last year preceding the visit, smoking status, alcohol consumption, physical activity, Townsend deprivation index, region (except for VAT and ASAT) and, for women, menopausal status and use of hormonal replacement therapy
¿¬±¸ °á°ú, ÀϹÝÀûÀÎ ºñ¸¸ÀΠù¹ø° À¯Çü»Ó ¾Æ´Ï¶ó ÀϹÝÀûÀ¸·Î '»ç°ú üÇü'À¸·Î ¾Ë·ÁÁø Ç㸮°¡ µÎ²®°í ¾ûµ¢ÀÌ°¡ Á¼Àº ¼¼ ¹ø° À¯Çüµµ ´ëÀå¾Ï ¹ßº´ À§ÇèÀÌ ³ô´Ù´Â »ç½ÇÀÌ È®ÀεǾú´Ù. ¿¬±¸ÆÀÀº »ç°ú üÇüÀº 'Áö¹æ Á¶Á÷'¿¡¼ °ú´Ù ¹ßÇöµÇ´Â À¯ÀüÀÚ¿Í °ü·ÃÀÌ ÀÖ´Ù´Â Á¡À» ¹ß°ßÇß´Ù. ¶ÇÇÑ, µ¿ÀÏÇÑ Å°¿Í üÁßÀÇ °³ÀÎ Áß ³»Àå Áö¹æ Á¶Á÷(VAT)Àº "¹è"°¡ °¡Àå ³·°í "»ç°ú"°¡ °¡Àå ³ô¾ÒÀ¸¸ç, º¹ºÎ ÇÇÇÏ Áö¹æ Á¶Á÷(ASAT)Àº "½½¸²"ÀÌ °¡Àå ³·°í "¿ÍÀ̵å"°¡ °¡Àå ³ô°Ô ³ªÅ¸³µ´Ù. Á¤»ó üÁßÀÇ "¹è"¿¡ ºñÇØ ³²¼ºÀÇ ´ëÀå¾Ï À§Çè(1029°Ç)Àº Á¤»ó üÁßÀÇ "»ç°ú" Ç¥ÇöÇü(À§Çèºñ HR = 1.77; 95% ½Å·Ú±¸°£: 1.16-2.69)¿¡¼ ´õ ³ô¾ÒÀ¸¸ç °úüÁß¿¡¼µµ ÀÌ¿Í ºñ½ÁÇÏ°Ô ³ªÅ¸³µ´Ù. ¿©¼º(889°Ç)ÀÇ ´ëÀå¾Ï À§Çè°úÀÇ ¿¬°ü¼ºÀº ´õ ¾àÇÏ°Ô ³ªÅ¸³µ´Ù.
Fig. 2 Body-shape phenotypes in relation to colon cancer risk. ABSI – a body shape index (cut-offs: ≥80 in men; ≥73 in women); Apple – largeABSI-small-HI; BMI – body mass index; CI – confidence interval; HI – hip index (cut-offs: ≥49 in men; ≥64 in women); HR – hazard ratio; NW – normal weight BMI ≥ 18.5 to < 25.0 kg/m2 ; OB – obese BMI ≥ 30.0 to < 45.0 kg/m2 ; OW – overweight BMI ≥ 25.0 to < 30.0 kg/m2 ; Pear – smallABSI-large-HI; Slim – small-ABSI-small-HI; Wide – large-ABSI-large-HI; HR (95% CI) – derived from cox proportional hazards models, stratified by age and region and adjusted for BMI (for overall), height, self-reported weight change within the year preceding the visit, smoking status, alcohol consumption, physical activity, Townsend deprivation index, diet (consumption of fresh fruit and vegetables, red meat, processed meat, fibre), use of non-steroidal anti-inflammatory drugs, family history of cancer and, in women, menopausal status, use of oral contraceptives and hormonal replacement therapy and age at the last live birth (Ãâó : BMC Cancer, doi: 10.1186/s12885-021-08820-6)
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ÀÇ°úÇבּ¸Á¤º¸¼¾ÅÍ(MedRIC) Á¦°ø
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References
Mayo Clinic, Metabolic syndrome URL: https://www.mayoclinic.org/diseases-conditions/metabolic-syndrome/symptoms-causes/syc-20351916
Association of body-shape phenotypes with imaging measures of body composition in the UK Biobank cohort: relevance to colon cancer risk (2021), BMC Cancer, doi: 10.1186/s12885-021-08820-6.
Associations of body shape index (ABSI) and hip index with liver, metabolic, and inflammatory biomarkers in the UK Biobank cohort (2022), Nature, doi: 10.1038/s41598-022-12284-4